TT2016 – President’s Synopsis

The opening night of TT2016 was momentous promising subsequent days filled with good friends and good science. We welcomed more than 700 delegates who attended, and then proceeded to hear a wonderful talk from Andras Nagy (2005 ISTT Prize winner). Andras’ talk was followed by a delicious buffet with wine, friends, colleagues and music. The opening proved to be an excellent portent of what was to come. Over the next three days, we heard many excellent talks—talks that encompassed the use of transgenic technologies, and especially CRISPR/Cas9 technology.

Charles Gersbach presents CRISPR/Cas9 modification of the dystrophin gene
Charles Gersbach presents CRISPR/Cas9 modification of the dystrophin gene

We heard about methods to ameliorate muscular dystrophy, to humanize large animals for xenotransplantation, to make swine resistant to an endemic disease, and to examine infertility in humans. We discussed technologies that would use epigenome to target the “regulome”, that would examine non-coding areas of the genome, that would recapitulate immune syndromes in ES cells, and that would allow us to assess phenotypic changes in embryonic lethal mutant mice using imaging. We learned both the history behind the CRISPR/Cas9 system, and newer CRISPR systems that are in development. We discussed ethics, gene drive, non-injection technologies, new injection technologies, and methods of generating many more oocytes in mice. There were seventeen abstracts chosen for full presentation, examining technological developments, large CRISPR/Cas9 initiatives, and transposon-mediated transgenesis. The remainder of the more than 125 abstract submssions were displayed throughout the meeting in the spacious poster room. Three were chosen as Poster Award winners, including Vera Jansen (Optogenetic tools to study cAMP signaling in cilia and flagella), Charles-Etienne Dumeau (Efficient method for the isolation of functional single cell from the ICM of mouse blastocyst), and Hiromi Miura (Generation of knockdown mice by CRISPR/Cas9-based targeted insertion of artificial miRNA sequence). On the last day, the ISTT Young Investigator Award (sponsored by inGenious Targeting Laboratory) was given to Pablo Ross based on his work developing ES cells in farm animals.

Charles River Representative, Iva Morse, and Jan Parker-Thornburg and Elizabeth Williams (ISTT, Inc.) present the Best Poster Awards to Vera Jansen (absent), Charlie
Iva Morse (Charles River), and Jan Parker-Thornburg and Elizabeth Williams (ISTT, Inc.) present the Best Poster Awards to Vera Jansen (absent), Charles-Etienne Dumeau, and Hiromi Miura (represented by Masato Ohtsuka).
Thomas Zeyda (inGenious Targeting Laboratory) and Jan Parker-Thornburg (ISTT President) present the Young Investigator Award to Dr. Pablo Ross, UC Davis.
Thomas Zeyda (inGenious Targeting Laboratory) and Jan Parker-Thornburg (ISTT President) present the Young Investigator Award to Dr. Pablo Ross, UC Davis.
TT2016 - Cryopreservation Workshop presentation by Lluis Montoliu.
TT2016 – Cryopreservation Workshop presentation by Lluis Montoliu.

The meeting was preceded by two workshops—one on programmable nucleases (headed by Radislav Sedlacek) and one on cryopreservation (led by Martin Fray, INFRAFRONTIER). Those who attended the workshops were very pleased with the learning opportunities that were afforded them. In addition, immediately following the meeting was one additional workshop on zebrafish transgenesis (Leads: Petr Bartunek, Zbynek Kozmik, Christian Mosimann and Graham Lieschke). All of the workshops were well-attended and greatly appreciated!

First Orbis pictus lecture given by Richard Behringer.
First Orbis pictus lecture given by Richard Behringer.

There were a number of new initiatives at TT2016. We had Orbis pictus lectures—lectures designed to use pictures and clear descriptions to demonstrate answers to a problem. Richard Behringer gave an excellent, encyclopedic presentation of methods of producing genetically modified animals in a vast variety of species. Later, Thomas Boehm described how lymphoid organs developed throughout evolution to the point where vertebrates now have a thymus. Also, for the first time, we had concurrent sessions. Delegates needed to choose whether to hear about ethics in animal use, or new injection and superovulation technologies. Overall, the scientific program was exceptional!

Departing Board members
Presentation of thank-you gifts to departing ISTT Board members – Wojtek Auerbach (absent), Boris Jerchow, and Tom Fielder.

The ISTT, Inc. held its third General Assembly just prior to the Gala Dinner. During that meeting, we sadly said goodbye to three departing Board members: Tom Fielder, Boris Jerchow and Wojtek Auerbach. We also reviewed ISTT finances, membership, committee activities, and interactions with our affiliated organizations. One new ISTT initiative that was presented was an outreach committee to our members (and non-members) who perform transgenic technologies in non-rodent (generally large-animal) species. The ISTT large animal group will be headed by Martina Crispo and Bruce Whitelaw. The meeting ended with a presentation inviting membership to attend TT2017 in Salt Lake City, Utah, USA, hosted by Susan Tamowski.

A wonderful time at the Zofin Palace.
A wonderful time at the Zofin Palace.

The social program prepared by our Czech colleagues was also amazing. Delegates enjoyed the opening buffet with traditional Czech music. However, it was the Gala Dinner that proved to be the high point of the social program. The Zofin Palace was full with partygoers. The wine flowed freely, the food was wonderful, and the string quartet (plus clarinet) fantastic as well. Overall, TT2016 can be considered as one of the best TT meetings ever, and I am proud, as ISTT President, that we helped to host such a wonderful meeting. Thanks so very much to the organizers—Radislav Sedlacek, Inken Beck and Nicole Chambers. Due to their amazing work, the ISTT has again had a successful TT meeting!

Fourth ISTT Young Investigator Award

ISTTlogo2ISTT-ingenious

The International Society for Transgenic Technologies (ISTT), in collaboration with ingenious targeting laboratory, has established the ISTT YOUNG INVESTIGATOR AWARD that is presented at each Transgenic Technology meeting. The fourth edition of this ISTT Young Investigator Award will be given at the next 13th Transgenic Technology Meeting (TT2016), that will be held in Prague, on 20-23 March 2016.

The ISTT Young Investigator Award recognizes outstanding achievements by a young scientist who will keep the field of transgenic technologies vibrant with new ideas and who has recently received his or her advanced professional degree. The ISTT Young Investigator Award is generously sponsored by ingenious targeting laboratory.

To date, the ISTT Young Investigator Awards has been granted to Dr. Xiao-Yang Zhao (TT2011), Dr. Toru Takeo (TT2013) and Dr. Feng Zhang (TT2014).

The ISTT Young Investigator Award is associated to funds that will serve to defray the costs related to the participation of the ISTT Young Investigator awardee at the corresponding TT Meeting, including: TT meeting registration fee, travel expenses to the TT meeting venue and accommodation during the meeting dates for the awarded candidate, with a maximum being set to 1500 Euros. All ISTT Young Investigator awardees will be given 1 year Ordinary ISTT Membership and a diploma, that will be provided at the ISTT Awards Ceremony, within the TT Meeting Program.

Instructions for participating and additional information are provided at the ISTT Young Investigator Award web page, within the ISTT web site.

ELEGIBILITY criteria for ISTT Young Investigator Awards

Nominees must be active in research, in the field of transgenic technologies, at the time the award is given. Nominees must have received a PhD or MD (or equivalent) within the past 10 years.

NOMINATION criteria for ISTT Young Investigator Awards

Nominations must be made or endorsed by an ISTT member. Nominee does not have to be an ISTT member. Self nomination is not permitted. No person may nominate more than one candidate.

PROCEDURE for participating in the ISTT Young Investigator Awards selection process

Nominations must be made or endorsed by an ISTT member and should include:

  • the CV of the nominee
  • a document highlighting the achievements made by the nominee in the field of transgenic technologies
  • a message or document confirming the nominee’s acceptance to participate in the ISTT Young Investigator Award selection process

All documents should be sent by the ISTT Member nominating the candidate to the ISTT email address: istt@transtechsociety.org

Currently we are accepting nominations for the 4th ISTT Young Investigator Award for the TT2016 meeting in Prague.

DEADLINE for submitting nominations: September 15, 2015.

Decision for the TT2014 ISTT Young Investigator Award will be communicated by October 15, 2015.

On behalf of the ISTT, I would like to thank ingenious targeting laboratory for their support to the ISTT and, in particular, for sponsoring this 4th ISTT Young Investigator Award.

With my best regards, Benoît Kanzler, ISTT Vice-President

ISTT Awarded Scientists

ISTT Awarded Scientists (2001-2014). Outstanding researchers in the field of Transgenic Technologies that have been awarded the ISTT Prize or the ISTT Young Investigator Award
ISTT Awarded Scientists (2001-2014). Outstanding researchers in the field of Transgenic Technologies that have been awarded the ISTT Prize or the ISTT Young Investigator Award

The International Society for Transgenic Technologies (ISTT) has updated its web site and now includes, in its public pages, additional information for all the awarded scientists, outstanding researchers in the field of Transgenic Technologies, which have been awarded the ISTT Prize, generously sponsored by genOway, or the ISTT Young Investigador Award, generously sponsored by ingenious targeting laboratory.

These are the 10 outstanding scientists awarded the ISTT Prize for the period 2001-2014. The ISTT was founded in 2006 and the first ISTT Prize was awarded in Toronto, at the TT2008 meeting. Previously, these awards were known as the genOway Prize for transgenic technologies.

  • Janet Rossant, 10th ISTT Prize, TT2014 meeting, Edinburgh, UK
  • Allan Bradley, 9th ISTT Prize, TT2013 meeting, Guangzhou, China
  • Ralph L. Brinster, 8th ISTT Prize, TT2011 meeting, Florida, USA
  • A. Francis Stewart, 7th ISTT Prize, TT2010 meeting, Berlin, Germany
  • Brigid Hogan, 6th ISTT Prize, TT2008 meeting, Toronto, Canada
  • Charles Babinet, 5th genOway Prize, TT2007 meeting, Brisbane, Australia
  • Andras Nagy, 4th genOway Prize, TT2005 meeting, Barcelona, Spain
  • Qi Zhou, 3th genOway Prize, TT2004 meeting, Uppsala, Sweden
  • Kenneth J. McCreath, 2nd genOway Prize, TT2002 meeting, Munich, Germany
  • Teruhiko Wakayama, 1st genOway Prize, TT2001 meeting, Stockholm, Sweden

These are the 3 outstanding researchers awarded the ISTT Young Investigator Award for the period 2011-2014

  • Feng Zhang, 3rd ISTT Young Investigator Award, TT2014 meeting, Edinburgh, UK
  • Toru Takeo, 2nd ISTT Young Investigator Award, TT2013 meeting, Guangzhou, China
  • Xiao-Yang Zhao, 1st ISTT Young Investigator Award, TT2011 meeting, Florida, USA

Feng Zhang receives his ISTT Diploma as Young Investigator Awardee

Feng Zhang (BROAD institute-MIT) receives his ISTT Diploma as Young Investigator Awardee from Changhong Pang (ingenious targeting laboratory)
Feng Zhang (BROAD institute-MIT) receives his ISTT Diploma as Young Investigator Awardee from Changhong Pang (ingenious targeting laboratory)

The 3rd ISTT Young Investigator Awardee, Feng Zhang (BROAD institute, MIT) receives the ISTT Diploma from Changhong Pang (ingenious targeting laboratory) in his lab, at the BROAD institute, after the TT2014 meeting held in Edinburgh. Congratulations to Feng Zhang and many thanks to ingenious targeting laboratory for their generous support to these ISTT Young Investigator Awards!

Welcome to Edinburgh, the city hosting the TT2014 meeting!

Welcome to Edinburgh, the city hosting the TT2014 meeting!
Welcome to Edinburgh, the city hosting the TT2014 meeting!

The 12th Transgenic Technology Meeting is about to begin this forthcoming weekend. On Sunday, 5 October, the Organizers have nicely prepared a welcome pre-meeting dinner to get together and meet all colleagues attending. The real TT2014 meeting‘s kick off will be on Monday morning, 6 October. During the following three days all delegates will have the pleasure (and the privilege, owing the great interest triggered by this conference, absolutely sold out) to listen and discuss the latest advances in transgenic technologies, through lectures delivered by the key players in our field, the ones that have developed or contributed to disseminate the use of the newest tools, the most updated experimental strategies applied to generate and analyze genetically modified animals. More than 530 participants will fill the Assembly Rooms in the historic city of Edinburgh. This TT meeting has become not only the most popular ISTT conference organized to date but also the TT meeting where the highest number of posters (176) will be shown. Therefore, besides enjoying the talks, all TT2014 delegates will have a unique opportunity to browse through the work of dozens of many other laboratories and facilities, willing to share their advances, problems encountered, solutions found and innovative proposals.

The International Society for Transgenic Technologies (ISTT) is proud to have chosen Edinburgh as the venue for TT2014 and, hence, wants to congratulate the Organizing Team, led by Douglas Strathdee, Chair of the conference, along with Peter Hohenstein and Bruce Whitelaw, co-chairs, the technical secretariat provided by In-Conference and the rest of members of the Organizing committees, for having prepared what surely will be another great TT meeting, as all precedent meetings were. The TT2014 meeting will be followed by a practical workshop on Zebrafish Transgenic Techniques, where a limited number of participants will have the opportunity to meet experts in the field and learn the basic techniques applied nowadays to use this vertebrate as an alternative animal model to study gene function or disease.

If you are already in Edinburgh, enjoy the city! If you are travelling to Edinburgh: have a safe trip! If, however, and unfortunately, you have not managed to attend this time, but you are a member of the ISTT, please wait to grasp some of the excellence and talent that will be presented during next week through the talks that we will be at the members-only area, after obtaining the consent from the corresponding speakers. Also, life goes on, and ISTT is already planning for the next TT meeting, already launched: the 13th Transgenic Technology Meeting (TT2016) that will be held in Prague (Czech Republic) in March 2016, organized by Radislav Sedlacek.

See you all soon in Edinburgh!

 

CRISPR-Cas resources at the ISTT web site

CRISPR-Cas resources at the ISTT web site. Illustration from: CRISPR-Cas technology and applications (video by Le Cong from Feng Zhang's lab at MIT/BROAD institute. This video has been made possible thanks to Addgene)
CRISPR-Cas resources at the ISTT web site. Illustration from: CRISPR-Cas technology and applications (video by Le Cong from Feng Zhang’s lab at MIT/BROAD institute. This video has been made possible thanks to Addgene)

CRISPR-Cas strategies are discussed and applied everywhere for the targeted modification of genomes. Every day a new lab is considering using CRISPR-Cas for the generation of their subsequent animal mutants. There are many papers regularly being published on this subject and a number of excellent online resources have been prepared by several labs actively working in this field. For newcomers/beginners this might seem (and it is) a lot of information, potentially difficult to digest.

In this regard, from the International Society for Transgenic Technologies (ISTT), we have prepared a simple web page containing a selection of CRISPR-Cas resources and related information, for anyone willing to start using these technologies. Please, feel free to suggest any additional CRISPR-Cas resources you might be aware/using/have developed, which might be worth including in these web pages. Thanks.

In particular, we wish to thank Feng Zhang (MIT/BROAD) and his lab for their efforts, videos (such as this video from Le Cong, PhD, illustrating this post, this video has been made possible thanks to Addgene, and is part of this series), online desing tools, protocols, etc… disseminating these technologies. Feng Zhang will receive the third ISTT Young Investigator Award and will attend the TT2014 meeting in Edinburgh.

The 3rd ISTT Young Investigator Award goes to Feng Zhang

The 3rd ISTT Young Investigator Award goes to Feng Zhang (picture kindly provided by the Broad Institute of MIT and Harvard)
The 3rd ISTT Young Investigator Award goes to Feng Zhang (picture kindly provided by the Broad Institute of MIT and Harvard)

The International Society for Transgenic Technologies (ISTT) is pleased to announce the awardee for the third (3rd) ISTT Young Investigator Award, generously sponsored by inGenious Targeting Laboratory (iTL). After careful evaluation of the nominated candidates, the Award Committee selected Dr. Feng Zhang (Broad Institute of MIT and Harvard; the McGovern Institute for Brain Research at MIT; and the Departments of Brain and Cognitive Sciences, and Biological Engineering at MIT, Cambridge, MA, USA).

Zhang’s recent outstanding work in the development of the CRISPR-Cas technology has set the pace in this highly competitive field. Among his many seminal contributions to CRISPR-Cas technology is the engineering of the RNA-guided nuclease Cas9 for use in editing the mammalian genome. This and his other recently published works have clearly impacted the field of transgenic technologies. Moreover, Zhang has encouraged transparency in the development of CRISPR-Cas technology and has made his work accessible for use by the broader scientific community.

Zhang was born in Shijiazhuang (Hebei Province, China) in 1981 and moved to the USA in 1993, where he was educated and trained at various institutes, including the Human Gene Therapy Research Institute (Des Moines, IA, 1997-99) as a high school student and the Department of Chemistry and Chemical Biology (2000-2004) at Harvard University (Cambridge, MA), where he obtained before his A.B. degree in Chemistry and Physics. He then moved to Stanford University (Stanford, CA) to conduct his PhD work (2004-2009) under the supervision of Dr. Karl Deiseroth in the Department of Bioengineering, obtaining his Ph.D. degree in Chemistry in 2009. As a graduate student, Dr. Zhang worked with Deisseroth to invent a set of technologies for dissecting the functional organization of brain circuits, using light-sensitive proteins from green algae and other microbes to develop a new “optogenetic” toolbox for controlling the activity of neurons in live organisms with light.

After finishing his Ph.D., he returned to Cambridge, MA, as a Junior Fellow at the Harvard Society of Fellows (2009-2010) and began his own laboratory at the Massachusetts Institute of Technology (MIT) in 2011 as an Assistant Professor. He has achieved great success and has shown strong leadership as a Core Member of the Broad Institute of MIT and Harvard; as an Investigator of the McGovern Institute for Brain Research at MIT; and as a W. M. Keck Career Development Professor in Biomedical Engineering, in the Departments of Brain and Cognitive Sciences and Biological Engineering at MIT. Dr. Zhang provides an excellent example of how scientific questions lead to the development and utilization of new technologies, as is reflected by his widespread research as an investigator at these various institutions.

Dr. Zhang has already received numerous prizes, awards and distinctions, including: the Perl/UNC Prize in Neuroscience, the NIH Director’s Pioneer Award, technology innovation awards from the McKnight and Damon Runyon Foundations, and the NSF Alan T. Waterman Award. He was also recently named one of the “Brilliant Ten” top minds in science by Popular Science, and also named by Nature as one of their top 10 scientists who mattered in 2013. Dr. Feng Zhang is also a co-founder of the popular non-profit molecular biology web app everyVECTOR.

The following articles represent only some of his recent research published in the last two years, highlighting his most recent contributions to the CRISPR-Cas field and related publications on other editing nucleases systems. These publications have had a tremendous impact in the animal transgenesis field and have rapidly become highly sought-after references for subsequent studies.

The 2014 ISTT Young Investigator Award Committee was formed by Dr. Lluis Montoliu (President of ISTT), Dr. Benoît Kanzler (Vice-President of ISTT, Chair) and Dr. Paul Sheiffele (iTL CEO). Dr. Feng Zhang was nominated by ISTT Member Dr. Jan Parker-Thornburg (MD Anderson Cancer Centre, Houston, TX, USA).

Dr. Feng Zhang will attend the next 12th Transgenic Technology (TT2014) meeting in Edinburgh (Scotland, UK, 6-8 October 2014) where he will receive the corresponding diploma and will deliver a talk summarizing the scientific achievements that led him to receive this 3rd ISTT Young Investigator Award, sponsored by inGenious Targeting Laboratory (iTL).

Download this Press Release as a PDF document

Third ISTT Young Investigator Award

Third ISTT Young Investigator Award
Third ISTT Young Investigator Award

The International Society for Transgenic Technologies (ISTT), in collaboration with inGenious Targeting Laboratory (iTL), has established the ISTT YOUNG INVESTIGATOR AWARD that is presented at each Transgenic Technology meeting. The third edition of this ISTT Young Investigator Award will be given at the next 12th Transgenic Technology Meeting (TT2014), that will be held in Edinburgh, on 6-8 October 2014.

The ISTT Young Investigator Award recognizes outstanding achievements by a young scientist who will keep the field of transgenic technologies vibrant with new ideas and who has recently received his or her advanced professional degree. The ISTT Young Investigator Award is generously sponsored by inGenious Targeting Laboratory (iTL).

To date, two editions of the ISTT Young Investigator Awards have been already granted to Dr. Xiao-Yang Zhao (China) and Dr. Toru Takeo (Japan), at the corresponding TT2011 and TT2013 meetings, respectively.

The ISTT Young Investigator Award is associated to funds that will serve to defray the costs related to the participation of the ISTT Young Investigator awardee at the corresponding TT Meeting, including: TT meeting registration fee, travel expenses to the TT meeting venue and accommodation during the meeting dates for the awarded candidate, with a maximum being set to 1500 Euros. All ISTT Young Investigator awardees will be given 1 year Ordinary ISTT Membership and a diploma, that will be provided at the ISTT Awards Ceremony, within the TT Meeting Program.

Instructions for participating and additional information are provided at the ISTT Young Investigator Award web page, within the ISTT web site.

ELEGIBILITY criteria for ISTT Young Investigator Awards

Nominees must be active in research, in the field of transgenic technologies, at the time the award is given. Nominees must have received a PhD or MD (or equivalent) within the past 10 years.

NOMINATION criteria for ISTT Young Investigator Awards

Nominations must be made or endorsed by an ISTT member. Nominee does not have to be an ISTT member. Self nomination is not permitted. No person may nominate more than one candidate.

PROCEDURE for participating in the ISTT Young Investigator Awards selection process

Nominations must be made or endorsed by an ISTT member and should include:

  • the CV of the nominee
  • a document highlighting the achievements made by the nominee in the field of transgenic technologies
  • a message or document confirming the nominee’s acceptance to participate in the ISTT Young Investigator Award selection process

All documents should be sent by the ISTT Member nominating the candidate to the ISTT email address: istt@transtechsociety.org

Currently we are accepting nominations for the 3rd ISTT Young Investigator Award for the TT2014 meeting in Edinburgh.

DEADLINE for submitting nominations: March 29, 2014.

Decision for the TT2014 ISTT Young Investigator Award will be communicated by May 31, 2014.

On behalf of the ISTT, I would like to thank inGenious Targeting Laboratory for their support to the ISTT and, in particular, for sponsoring this 3rd ISTT Young Investigator Award.

With my best regards,

Benoît Kanzler

ISTT Vice-President

The 2nd ISTT Young Investigator Award goes to Toru Takeo

Dr. Toru Takeo (Center for Animal Resources and Development, Kumamoto University, Japan). 2nd ISTT Young Investigator Award.
Dr. Toru Takeo (Center for Animal Resources and Development, Kumamoto University, Japan). 2nd ISTT Young Investigator Award.

The International Society for Trangenic Technologies (ISTT) is pleased to announce the second (2nd) ISTT Young Investigator Award, generously sponsored by inGenious Targeting Laboratory. The Award Committee carefully evaluated the excellent merits presented by all nominated candidates and decided to select Dr. Toru Takeo (Center for Animal Resources and Development, Kumamoto University, Japan) for the second ISTT Young Investigator Award. Dr. Toru Takeo was nominated by Dr. Jan Parker-Thornburg (ISTT Member, ISTT Council). The Award committee considered that Dr. Toru Takeo’s work represented a major improvement of mouse sperm cyropreservation and IVF techniques, thereby greatly facilitating the archiving and sharing of many mouse models produced by the transgenic community.

Dr. Toru Takeo, working in Dr. Naomi Nakagata’s laboratory, at CARD-KU, in Kumamoto (Japan), described three major technical improvements for boosting the efficiency of mouse sperm cryopreservation and the subsequently required IVF technique. The three fundamental modifications he reported in his recent publications tackled all three important steps in sperm cryopreservation and IVF, namely: (1) improving the cryopreservation of spermatozoa by adding L-Glutamine to the cryoprotective agent (CPA); (2) improving the number of capacitated sperm, upon thawing and pre-incubating them with Methyl-Beta-CycloDextrin (MBCD) by reducing the cholesterol levels in plasma membrane and increasing fertilization rate; and, (3) improving the in vitro fertilization (IVF) step itself, by adding reduced glutathione (GSH) to the IVF medium thereby increasing periviteline space in oocytes and the number of free thiols in the zona pellucida (ZP), greatly facilitating ZP penetration by sperm cells and, hence, fertilization. The three modifications, when jointly applied to some common mouse inbred strains, traditionally difficult to archive due to known poor sperm cryopreservation performance and limited IVF success, like C57BL/6J mice, boosted IVF efficiencies to >80%, and resulted in a true revolution in the transgenic mouse community and public archives. For example, at the European Mouse Mutant Archive (EMMA), a number of nodes have already updated their routine sperm cryopreservation and IVF methods according to Dr. Toru Takeo’s reports and succeeded in reproducing CARD innovations.

Dr. Toru Takeo’s three main publications on this subject are:

Takeo T, Nakagata N.
Reduced glutathione enhances fertility of frozen/thawed C57BL/6 mouse sperm after exposure to methyl-beta-cyclodextrin.
Biol Reprod. 2011 Nov;85(5):1066-72.

Takeo T, Nakagata N.
Combination medium of cryoprotective agents containing L-glutamine and methyl-{beta}-cyclodextrin in a preincubation medium yields a high fertilization rate for cryopreserved C57BL/6J mouse sperm.
Lab Anim. 2010 Apr;44(2):132-7.

Takeo T, Hoshii T, Kondo Y, Toyodome H, Arima H, Yamamura K, Irie T, Nakagata N.
Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells.
Biol Reprod. 2008 Mar;78(3):546-51.

Dr. Toru Takeo was born in 1979. In 2003, he obtained a Bachelor degree in Pharmaceutical Sciences at the University of Kumamoto and, subsequently, he continued his studies at the Graduate School of Pharmaceutical Sciences obtaining a Master degree in Pharmaceutical Sciences in 2005 and his PhD degree in Pharmaceutical Sciences in 2008. Thereafter, he has worked as postdoctoral researcher at the Division of Reproductive Engineeting, of the Center for Animal Resources and Development (CARD)-University of Kumamoto and, in 2010, he was promoted to Assistant Professor. He currently holds several professional memberships at various Societies, including the Japanese Association for Laboratory Animal Science, the Japan Pharmaceutical Association, The Pharmaceutical Society of Japan and the Society for Reproduction and Development, Japan, and his excellent work has already been awarded several times, including his most recent 2012 Young Investigator Award, by the Japanese Association for Laboratory Animal Science.

The 2012 ISTT Young Investigator Award Committee was formed by Dr. Lluis Montoliu (President of ISTT)-Chair, Dr. Thom Saunders (Vice-President of ISTT), Dr. Boris Jerchow (ISTT Council member), Dr. Paul Sheiffele (iTL CEO) and Dr. Lisa Aronov (iTL).

Dr. Toru Takeo will attend the next 11th Transgenic Technology (TT2013) meeting where he will receive the corresponding diploma and will deliver a short talk summarizing his scientific achievements that led him to receive this 2nd ISTT Young Investigator Award, sponsored by inGenious Targeting Laboratory (iTL).

Download this ISTT Press Release

the ISTT Young Investigator Award, sponsored by iTL
the ISTT Young Investigator Award, sponsored by iTL

	

Haven’t you registered yet for the TT2013 meeting? China is waiting for you!

Time to register for the next ISTT meeting, TT2013, in China, 25-27 Feb 2013
Time to register for the next ISTT meeting, TT2013, in China, 25-27 Feb 2013

Dear colleagues and friends,

Time is running fast and we are progressively approaching the deadline for early bird registration at reduced fees to attend the next meeting of the International Society for Transgenic Technologies (ISTT), the 11th Transgenic Technology meeting, TT2013, which will be held in Guangzhou (PR China), on 25-27 February 2013. The ISTT family will visit Asia for the first time and we are all very excited about this forthcoming TT2013 meeting, organized by the ISTT member Prof. Ming Zhao (Southern Medical University, Guangzhou, PR China) and his team of colleagues and collaborators. As many as 32 international experts in our field will attend and share their latest results and developments regarding applications, methods and practices for the generation and analyses of genetically modified animals. Do not miss this opportunity to review and update your knowledge on state-of-art animal transgenesis technologies and enjoy attending the next edition of the renowned TT meeting series, periodically organized by the ISTT. You can download here, the latest TT2013 meeting program and TT2013 meeting flyer where you will find the names of confirmed invited speakers and selected hot topics in our field that will be covered during this conference.

TT2013 meeting registration fees have been maintained at reasonably reduced prices, similar to previous TT meetings. ISTT members are entitled to reduced registration fees. If you are not yet a member of the ISTT you may consider applying for ISTT membership and, immediately next, registering for the TT2013 meeting and benefit of a reduced registration fee. Bank wire transfers are the recommended payment format for the TT2013 meeting.

At the TT2013 meeting, the ISTT will be awarding Prof. Allan Bradley (Wellcome Trust Sanger Institute, Hinxton, UK) the 9th ISTT Prize for his outstanding contributions to the field of transgenic technologies. The ISTT Prize is generously sponsored by genOway. In addition, the ISTT, in collaboration with inGenious Targeting Laboratory, will be also awarding the 2nd ISTT Young Investigator Award, for which candidates can be nominated by ISTT members. The ISTT will also provide several ISTT Registration Awards for ISTT members willing to attend the TT2013 meeting, according to the specified conditions.

We kindly invite you to submit your abstracts for this TT2013 meeting, detailing your most interesting and recent research, solutions, investigations or developments on any aspect related to animal transgenesis. Accepted abstracts will be eventually published in the scientific journal Transgenic Research (Springer), associated to the ISTT. A limited number of abstract submissions will be selected and invited to present their findings in the form of a short oral presentation within the main meeting program.

A three-day hands-on practical course on basic techniques in animal transgenesis will be held also held in Guangzhou, immediately following the TT2013 meeting, on 28 February-2 March 2013. This interesting workshop, limited to 30 participants, is organized by Wenhao Xu (University of Virginia, Charlottesville, VA, USA), Ming Zhao (Southern Medical University, Guangzhou, China), Jing An (Cancer Institute, Southern Medical University, Guangzhou, China) and Liangping Li (Sun Yat-sen University, Guangzhou, China) and will benefit by the participation of international experts and delegates from selected companies within our field as course instructors.

Besides exciting discussions on science and technology for the generation and analysis of transgenic animals, the TT2013 meeting will also provide opportunities to relax, meet and chat with your colleagues while visiting Guangzhou and its surrounding area. For the TT2013 meeting, the Organizers have prepared for participants a most interesting social program and after-meeting-tour including a pre-meeting dinner cruise on the Pearl River, a sightseeing tour in Guangzhou and an after meeting-tour to Beijing, the capital of PR China.

The TT2013 meeting venue and hotel will be at the Guangzhou Baiyun International Convention Center, the largest comprehensive international convention center with most advanced establishment and perfect supporting facilities for conferences in Southern China. Accommodation, at conveniently reduced prices, is offered for TT2013 meeting participants at the five-star hotel associated with this convention center and must be organized separately, directly by the participants, following the indications provided. Participants at the hands-on workshop will be lodged at The University Town International Hotel.

IMPORTANT INFORMATION FOR INTERNATIONAL PARTICIPANTS: There are certain documents all international participants willing to attend the TT2013 meeting must organize, previously, well in advance, to obtain granted permission to enter and visit China. These documents include a passport which should be valid for six months beyond the approved length of your stay in China, and a VISA. Please read carefully the indications and recommendations kindly prepared by TT2013 meeting organizers regarding how and what type of VISA every international participant attending this conference should apply for.

The important deadlines for the TT2013 meeting are:

Registration for the TT2013 meeting: OPEN
Submission of Abstracts: 15 October 2012
Application for ISTT Registration Awards: 15 October 2012
Nominations for ISTT Young Investigator Awards: 15 October 2012
Early bird registration deadline at reduced fees: 15 October 2012
Standard registration period deadline: 31 January 2013
Late registration fees & on-site registration: from 01 February 2013

Companies willing to exhibit their products and services at the TT2013 meeting are most welcome to participate and kindly invited to browse the TT2013 meeting sponsorship opportunities for both the main conference and the associated hands-on workshop.

TT2013 meeting contact email address: tt2013@transtechsociety.org

TT2013 meeting web site: http://www.tt2013.org

See you all in Guangzhou!

Lluis Montoliu, PhD
President of the ISTT