TT2016 – President’s Synopsis

The opening night of TT2016 was momentous promising subsequent days filled with good friends and good science. We welcomed more than 700 delegates who attended, and then proceeded to hear a wonderful talk from Andras Nagy (2005 ISTT Prize winner). Andras’ talk was followed by a delicious buffet with wine, friends, colleagues and music. The opening proved to be an excellent portent of what was to come. Over the next three days, we heard many excellent talks—talks that encompassed the use of transgenic technologies, and especially CRISPR/Cas9 technology.

Charles Gersbach presents CRISPR/Cas9 modification of the dystrophin gene
Charles Gersbach presents CRISPR/Cas9 modification of the dystrophin gene

We heard about methods to ameliorate muscular dystrophy, to humanize large animals for xenotransplantation, to make swine resistant to an endemic disease, and to examine infertility in humans. We discussed technologies that would use epigenome to target the “regulome”, that would examine non-coding areas of the genome, that would recapitulate immune syndromes in ES cells, and that would allow us to assess phenotypic changes in embryonic lethal mutant mice using imaging. We learned both the history behind the CRISPR/Cas9 system, and newer CRISPR systems that are in development. We discussed ethics, gene drive, non-injection technologies, new injection technologies, and methods of generating many more oocytes in mice. There were seventeen abstracts chosen for full presentation, examining technological developments, large CRISPR/Cas9 initiatives, and transposon-mediated transgenesis. The remainder of the more than 125 abstract submssions were displayed throughout the meeting in the spacious poster room. Three were chosen as Poster Award winners, including Vera Jansen (Optogenetic tools to study cAMP signaling in cilia and flagella), Charles-Etienne Dumeau (Efficient method for the isolation of functional single cell from the ICM of mouse blastocyst), and Hiromi Miura (Generation of knockdown mice by CRISPR/Cas9-based targeted insertion of artificial miRNA sequence). On the last day, the ISTT Young Investigator Award (sponsored by inGenious Targeting Laboratory) was given to Pablo Ross based on his work developing ES cells in farm animals.

Charles River Representative, Iva Morse, and Jan Parker-Thornburg and Elizabeth Williams (ISTT, Inc.) present the Best Poster Awards to Vera Jansen (absent), Charlie
Iva Morse (Charles River), and Jan Parker-Thornburg and Elizabeth Williams (ISTT, Inc.) present the Best Poster Awards to Vera Jansen (absent), Charles-Etienne Dumeau, and Hiromi Miura (represented by Masato Ohtsuka).
Thomas Zeyda (inGenious Targeting Laboratory) and Jan Parker-Thornburg (ISTT President) present the Young Investigator Award to Dr. Pablo Ross, UC Davis.
Thomas Zeyda (inGenious Targeting Laboratory) and Jan Parker-Thornburg (ISTT President) present the Young Investigator Award to Dr. Pablo Ross, UC Davis.
TT2016 - Cryopreservation Workshop presentation by Lluis Montoliu.
TT2016 – Cryopreservation Workshop presentation by Lluis Montoliu.

The meeting was preceded by two workshops—one on programmable nucleases (headed by Radislav Sedlacek) and one on cryopreservation (led by Martin Fray, INFRAFRONTIER). Those who attended the workshops were very pleased with the learning opportunities that were afforded them. In addition, immediately following the meeting was one additional workshop on zebrafish transgenesis (Leads: Petr Bartunek, Zbynek Kozmik, Christian Mosimann and Graham Lieschke). All of the workshops were well-attended and greatly appreciated!

First Orbis pictus lecture given by Richard Behringer.
First Orbis pictus lecture given by Richard Behringer.

There were a number of new initiatives at TT2016. We had Orbis pictus lectures—lectures designed to use pictures and clear descriptions to demonstrate answers to a problem. Richard Behringer gave an excellent, encyclopedic presentation of methods of producing genetically modified animals in a vast variety of species. Later, Thomas Boehm described how lymphoid organs developed throughout evolution to the point where vertebrates now have a thymus. Also, for the first time, we had concurrent sessions. Delegates needed to choose whether to hear about ethics in animal use, or new injection and superovulation technologies. Overall, the scientific program was exceptional!

Departing Board members
Presentation of thank-you gifts to departing ISTT Board members – Wojtek Auerbach (absent), Boris Jerchow, and Tom Fielder.

The ISTT, Inc. held its third General Assembly just prior to the Gala Dinner. During that meeting, we sadly said goodbye to three departing Board members: Tom Fielder, Boris Jerchow and Wojtek Auerbach. We also reviewed ISTT finances, membership, committee activities, and interactions with our affiliated organizations. One new ISTT initiative that was presented was an outreach committee to our members (and non-members) who perform transgenic technologies in non-rodent (generally large-animal) species. The ISTT large animal group will be headed by Martina Crispo and Bruce Whitelaw. The meeting ended with a presentation inviting membership to attend TT2017 in Salt Lake City, Utah, USA, hosted by Susan Tamowski.

A wonderful time at the Zofin Palace.
A wonderful time at the Zofin Palace.

The social program prepared by our Czech colleagues was also amazing. Delegates enjoyed the opening buffet with traditional Czech music. However, it was the Gala Dinner that proved to be the high point of the social program. The Zofin Palace was full with partygoers. The wine flowed freely, the food was wonderful, and the string quartet (plus clarinet) fantastic as well. Overall, TT2016 can be considered as one of the best TT meetings ever, and I am proud, as ISTT President, that we helped to host such a wonderful meeting. Thanks so very much to the organizers—Radislav Sedlacek, Inken Beck and Nicole Chambers. Due to their amazing work, the ISTT has again had a successful TT meeting!

The TT2016 ISTT Registration and ISTT & Genentech Travel Award Winners

The ISTT is proud to announce the winners of the TT2106 ISTT Registration Awards and the ISTT & Genentech Travel Awards.

This year, the ISTT Board of Directors has awarded 12 ISTT members an ISTT Registration Award, which will cover their registration fee for TT2016.

Registration Awardees

Congratulations to:

Samy Alghadban

Katherine Bovariak

Carmen Cucarella

Paul Devenney

Denise Grant Lanza

Melissa Larson

Peter Major

Anna Novoa

Sara Ortica

Karolina Piotrowska-Nitsche

Lucas Pitt

Selin Yagcioglu

 

Travel Awardees

The ISTT and Genentech have also awarded 2 of the successful applicants an additional travel award. The awardees are: Melissa Larson from the University of Kansas Medical Center, Kansas City, Missouri, USA and Sara Ortica Gatti from the Paris-Saclay Institute of Neuroscience, Paris, France. Their award includes airfare to and accommodation at TT2016. Both travel award winners will be presenting their work at the meeting.

Melissa Larson (left), Sara Ortica (right)
Melissa Larson (left), Sara Ortica (right)

 

Post prepared and submitted by Elizabeth Williams on behalf of the ISTT Board of Directors.

TT2016 Deadlines and Poster

TT2016, to be held in Prague in late March, should prove to be an exciting meeting. The scientific portion of the meeting will be from 20-23 March. In addition, there are three hands-on workshops that are available, including a Mouse Cryopreservation Workshop (16-18 March), a course on CRISPR/Cas9 programmable nucleases (16-18 March) and a Fish Transgenesis Course (23-25 March).

Early registration will close on 15 December, 2015, so register soon! Please note that ISTT members have discounted registrations, and can apply for a limited number of registration and travel awards (as detailed in e-mails sent to ISTT members). Applications and documentation for these awards must be sent in by 15 December, 2015 to istt@transtechsociety.org.

We also encourage you to submit an abstract for the poster session. A number of poster abstracts will be chosen for oral presentation, so this is an excellent opportunity to share your science. Poster submissions are also eligible for the TT2016 Poster awards. Abstracts are due by 15 December, 2015

Please note that a printable poster has been appended to this blog post. Feel free to print and post widely! Looking forward to seeing you at TT2016!

TT2016_poster A3w workshops

Newly elected 2016 ISTT Board of Directors members

ISTT BOD electees

Branko Zevnik Lynn Doglio Peter Hohenstein

The official results of the recent election for the ISTT Board of Directors are in, and we congratulate Branko Zevnik, Lynn Doglio and Peter Hohenstein on their election to the ISTT Board. Branko Zevnik (Cologne, Germany) is the head of the in vivo Research Facility at the University of Cologne. Lynn Doglio (Chicago, USA) is the Director of the Transgenic and Targeted Mutagenesis Laboratory at Northwestern University. Peter Hohenstein (Edinburgh, United Kingdom) is a Group Leader and Chair of the Small Animal Facility Management Committee at The Roslin Institute. All three candidates received the support of the majority of voting ISTT members. While they will start their three-year terms at TT2016 to be held in Prague, Czech Republic, they will be immediately appointed as Board members-elect. This will allow them to interact with the rest of the ISTT Board members and become familiar with the administration and management of the ISTT. Congratulations to all of them!

In addition, the ISTT would like to express its respect and sincere appreciation for the commitment and participation of all the candidates who were involved in the ISTT election process. As well, we would like to thank Tom Fielder, Wojtek Auerbach, and Boris Jerchow for their service on the ISTT Council and Board of Directors. These three Board members have contributed greatly to the management of the ISTT (and will continue to do so until TT2016). It is due in large part to the contributions of our members that we have the vibrant Society that we do.

Fourth ISTT Young Investigator Award

ISTTlogo2ISTT-ingenious

The International Society for Transgenic Technologies (ISTT), in collaboration with ingenious targeting laboratory, has established the ISTT YOUNG INVESTIGATOR AWARD that is presented at each Transgenic Technology meeting. The fourth edition of this ISTT Young Investigator Award will be given at the next 13th Transgenic Technology Meeting (TT2016), that will be held in Prague, on 20-23 March 2016.

The ISTT Young Investigator Award recognizes outstanding achievements by a young scientist who will keep the field of transgenic technologies vibrant with new ideas and who has recently received his or her advanced professional degree. The ISTT Young Investigator Award is generously sponsored by ingenious targeting laboratory.

To date, the ISTT Young Investigator Awards has been granted to Dr. Xiao-Yang Zhao (TT2011), Dr. Toru Takeo (TT2013) and Dr. Feng Zhang (TT2014).

The ISTT Young Investigator Award is associated to funds that will serve to defray the costs related to the participation of the ISTT Young Investigator awardee at the corresponding TT Meeting, including: TT meeting registration fee, travel expenses to the TT meeting venue and accommodation during the meeting dates for the awarded candidate, with a maximum being set to 1500 Euros. All ISTT Young Investigator awardees will be given 1 year Ordinary ISTT Membership and a diploma, that will be provided at the ISTT Awards Ceremony, within the TT Meeting Program.

Instructions for participating and additional information are provided at the ISTT Young Investigator Award web page, within the ISTT web site.

ELEGIBILITY criteria for ISTT Young Investigator Awards

Nominees must be active in research, in the field of transgenic technologies, at the time the award is given. Nominees must have received a PhD or MD (or equivalent) within the past 10 years.

NOMINATION criteria for ISTT Young Investigator Awards

Nominations must be made or endorsed by an ISTT member. Nominee does not have to be an ISTT member. Self nomination is not permitted. No person may nominate more than one candidate.

PROCEDURE for participating in the ISTT Young Investigator Awards selection process

Nominations must be made or endorsed by an ISTT member and should include:

  • the CV of the nominee
  • a document highlighting the achievements made by the nominee in the field of transgenic technologies
  • a message or document confirming the nominee’s acceptance to participate in the ISTT Young Investigator Award selection process

All documents should be sent by the ISTT Member nominating the candidate to the ISTT email address: istt@transtechsociety.org

Currently we are accepting nominations for the 4th ISTT Young Investigator Award for the TT2016 meeting in Prague.

DEADLINE for submitting nominations: September 15, 2015.

Decision for the TT2014 ISTT Young Investigator Award will be communicated by October 15, 2015.

On behalf of the ISTT, I would like to thank ingenious targeting laboratory for their support to the ISTT and, in particular, for sponsoring this 4th ISTT Young Investigator Award.

With my best regards, Benoît Kanzler, ISTT Vice-President

ISTT Registration Awards for TT2016 meeting in Prague

ISTT Registration Awards for TT2016 meeting in Prague
ISTT Registration Awards for TT2016 meeting in Prague

A minimum of six Registration Awards will be sponsored by the International Society for Transgenic Technologies for ISTT members wishing to attend the 13th Transgenic Technologies (TT2016) meeting in Prague, The Czech Republic, on 20-23rd March, 2016. Selected applicants will be awarded funding to cover registration fees plus attendance at all social events. However, the award does not cover travel expenses, hotel accommodation or attendance at pre-meeting events.

Applicants who are not yet members of the ISTT may join the ISTT and simultaneously submit their Registration Award application. Only those applications from members who have paid their current annual fees will be considered.

Procedure
Applicants must register first at the TT2016 Meeting website and select, as a payment method, “Application for Registration Awards” as a payment method. The ISTT will pay the Registration Fee of all applicants selected for an award. Applicants not selected will be kindly requested to pay the corresponding registration fee.
Applications and additional required documents (see below) should be sent, along with the meeting registration confirmation, to the official ISTT email address, istt@transtechsociety.org, by 30th November, 2015.

Additional Documentation Required
a) Applicant’s CV
b) For ordinary members, a letter from the applicant describing how he/she will benefit from attending the TT meeting
c) For technician/student members, a letter of support from the applicant’s PI or supervisor stating how attendance will benefit the applicant’s career

Selection Process
ISTT Registration awards will be selected by a subset of ISTT Council members, with preference given to:
1) Student/Technician ISTT Members
2) ISTT Members submitting an abstract for presentation as a poster/short-oral communication at the TT meeting
3) Any other ISTT Member

Decision
Awards to the selected applicants will be announced by December 15th, 2015 and awardees will receive a diploma marking the event at the end of the TT2016 Meeting.

Registration OPEN for the next (13th) Transgenic Technology (TT2016) meeting in Prague, Czech Republic, 20-23 March 2016

Registration OPEN for the next (13th) Transgenic Technology (TT2016) meeting in Prague, Czech Republic, 20-23 March 2016
Registration OPEN for the next (13th) Transgenic Technology (TT2016) meeting in Prague, Czech Republic, 20-23 March 2016

Dear colleagues,

we are pleased to announce that registration and abstract submission for the 13th Transgenic Technology Meeting (TT2016) in Prague, Czech Republic from 20th – 23rd March 2016 are now OPEN.

Andras Nagy will give the opening plenary lecture and Denis Duboule the closing one.
Thomas Boehm and Richard Behringer will give our special Orbis pictus lectures.

Further information can be found at the conference website.

We look forward to seeing you here in the beautiful city of Prague.

Radislav Sedlacek
Chair of the TT2016 Organizing Committee

TT2014 meeting report published in Transgenic Research

TT2014 meeting report published in Transgenic Research
TT2014 meeting report published in Transgenic Research

The meeting report of the 12th Transgenic Technology meeting (TT2014), held in Edinburgh on October 6-8, 2014, and organized by Douglas Strathdee, Peter Hohenstein and Bruce Whitelaw, has just been published in the scientific journal Transgenic Research.

TT2014 meeting report on the 12th Transgenic Technology meeting in Edinburgh: new era of transgenic technologies with programmable nucleases in the foreground.
Beck IM, Sedlacek R.
Transgenic Res. 2015 Feb;24(1):179-83.

The TT2014 meeting report has been written by Inken Beck and Radislav Sedlacek (Czech Centre for Phenogenomics, Institute of Molecular Genetics, Prague, Czech Republic), who will be responsible to organize the next (13th) Transgenic Technology meeting (TT2016) in Prague on March 20-23, 2016.

The TT2014 meeting Scottish style

The TT2014 meeting at the Assembly Rooms, Edinburgh, Scotland, UK, 6-8 October 2014
The TT2014 meeting at the Assembly Rooms, Edinburgh, Scotland, UK, 6-8 October 2014

The most popular ISTT meeting held to date took place last week in Edinburgh, UK, at the Assembly Rooms. More than 530 participants gathered in Scotland for the 12th Transgenic Technology (TT2014) meeting during three days, 6 to 8 October 2014, to discuss the latest advances in methods and applications for generating and analyzing genetically modified animals. The local Organizers, Douglas Strathdee, Peter Hohenstein and Bruce Whitelaw showed us how to run an splendid TT meeting Scottish style. The Organizing committee, helped by the In-Conference team and the ISTT council and Administration, should be praised for putting together an excellent collection of talks, covering the most up-to-date topics, where all participants could learn and share their experiences.

Janet Rossant awarded the 10th ISTT Prize at the TT2014 meeting in Edinburgh, for her outstanding contributions to the field of transgenic technologies. Janet Rossant appears in this picture with Alexandre Fraichard (left, genOway, CEO, sponsor of this award) and Lluis Montoliu (past-ISTT President, right)
Janet Rossant awarded the 10th ISTT Prize at the TT2014 meeting in Edinburgh, for her outstanding contributions to the field of transgenic technologies. Janet Rossant appears in this picture with Alexandre Fraichard (left, genOway, CEO, sponsor of this award) and Lluis Montoliu (past-ISTT President, right)

As many as 54 speakers were invited to present their research, including two keynote addresses (Rudolf Jaenisch, Alexandra Joyner), at the opening and clossing of the TT2014 meeting, two ISTT awarded scientists (Janet Rossant-10th ISTT Prize- and Feng Zhang-3rd ISTT Young Investigator Award), 26 invited speakers, 6 Showcase presentations from Scottish scientists, 5 short talks and 15 teasers selected from Poster abstracts. The impressive numbers of the TT2014 meeting continue with 176 Posters presented by participants attending the conference in Edinburgh and the many sponsors and exhibitors that generously contributed to the success of the 12th Transgenic Technology Meeting. The ISTT conference was followed by a hands-on workshop on basic zebrafish transgenic methods.

Lluis Montoliu, founder and past-ISTT President, awarded a sculpture representing a zygote, created by Bela Rozsnyay, by ISTT Board members for his dedicated work for the progress of the ISTT since inception of the Society and during the past 9 years (2006-2014). Lluis Montoliu appears next to Alison Cameron (ISTT Administrative Assistant) and Aimee Stablewski (ISTT Treasurer and Secretary)
Lluis Montoliu, founder and past-ISTT President, awarded a sculpture representing a zygote, created by Bela Rozsnyay, by ISTT Board members for his dedicated work for the progress of the ISTT since inception of the Society and during the past 9 years (2006-2014). Lluis Montoliu appears next to Alison Cameron (ISTT Administrative Assistant) and Aimee Stablewski (ISTT Treasurer and Secretary)

During the TT2014 meeting, at the corresponding ISTT General Assembly, the ISTT Members approved to dissolve the legal entity representing the Society in Spain, which has been substituted by the new legal entity, ISTT, Inc., a not-for-profit association registered in the New York State (USA) that from now onwards will be representing the interests of the Society. Also, during the course of the ISTT conference in Edinburgh, the ISTT Board members awarded Lluis Montoliu (Founder and Past-President of the ISTT, 2006-2014) and thanked his dedicated work for the ISTT, since its inception. Jan Parker-Thornburg is the new President of the ISTT.

The 13th Transgenic Technology Meeting, TT2016, will be held in Prague (Czech Republic) on 20-23 March 2016, organized by Radislav Sedlacek
The 13th Transgenic Technology Meeting, TT2016, will be held in Prague (Czech Republic) on 20-23 March 2016, organized by Radislav Sedlacek

The conference in Edinburgh concluded with the warm invitation by Radislav Sedlacek (IMG, Prague, Czech Republic), Organizer of the 13th Transgenic Technology Meeting, TT2016, to attend the next ISTT conference that will be held in Prague, Czech Republic, on 20-23 March 2016.

Good bye and thanks to Edinburgh! Hello and see you all again in Prague!

The TT2016 meeting will be held in Prague

The TT2016 meeting will be held in Prague
The TT2016 meeting will be held in Prague

From the International Society of Transgenic Technologies (ISTT), it is our pleasure to announce that the next, 13th, Transgenic Technology (TT) meeting, TT2016, will be held in Prague (Czech Republic), in March 2016, organized by Dr. Radislav Sedlacek (Associate Professor, Institute of Molecular Genetics; Head of Laboratory of Transgenic Models of Diseases; Project Director, Czech Centre for Phenogenomics; ISTT Member).

The ISTT was delighted to accept a very appealing and well-structured meeting proposal from Prague, a historical city lying in the heart of Europe. Prague is a beautiful city with magical atmosphere. It offers historical as well as modern hotels, restaurants, infrastructure and places of sightseeing. TT2016 conference delegates arriving in Prague will enjoy a high standard of hospitality at very reasonable prices.

The TT2016 meeting web site (http://www.transtechsociety.org/tt2016) and the official TT2016 meeting address (tt2016@transtechsociety.org) are already operative. Dr. Radislav Sedlacek will present the TT2016 meeting in Edinburgh, at the TT2014 meeting, introducing his team of collaborators, the organizing and advisory committees, their view, plans and expectations for this transgenic technology meeting, where again, and with the support of the ISTT, the Organizers will prepare a very attractive scientific program with all the newest techniques, applications and approaches developed in the field of animal transgenesis.

The TT2016 meeting will he held in Prague in March 2016. The exact dates and location of the conference venue will be communicated shortly.