LASA Winter Meeting – Genome Editing Session

Meeting Report by Mary-Ann Haskings, 25 November, 2015

It was a cold, sunny day in Brighton, UK for the LASA Winter meeting and we were pleased to see several ISTT members attending the meeting. The talks reflected on recent work involving genome editing across a breadth of species: mouse, zebrafish, opossum and discussion of use in humans.

There were some common themes across the talks and some newer approaches such as testis electroporation highlighted. The occurrence of mosaicism was discussed lengthily. The use of the NHEJ inhibitor SCR7 was another hot topic, with multiple speakers reporting that their experience suggested that there was little gain in using it. Comparisons were shown between Cas9 mRNA and protein; also the use of transgenic mice overexpressing Cas9 was reported. The possibility of reproducing better models of multi locus disease was recognised by several presenters.

The afternoon session focused on the ethical considerations of the technology, with the reminder that while it may well cause a reduction in numbers as we refine the production of genetically altered animals, the ease and efficiency of the technology may actually lead to a rise in the numbers of animals being used.

We closed with a round table discussion giving the audience the opportunity to ask any questions of our speakers. We need to thank all our speakers and our fantastic chairs Brendan Doe and Sarah Hart Johnson who helped the day to run so smoothly.

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