The International Society for Transgenic Technologies (ISTT) is pleased to announce the awardee for the 4th ISTT Young Investigator Award, generously sponsored by ingenious targeting laboratory (iTL). ISTT created the Young Investigator Award, with one goal: identify and recognize young scientists who will keep the field of transgenic technologies vibrant with new ideas and innovative research. After careful evaluation of the nominated candidates, the Award Evaluation Committee unanimously selected Dr. Pablo Ross (Department of Animal Sciences, University of California, Davis, CA, USA).
Pablo is perfectly fitting with the criteria required for this price. Veterinarian by training, gaining his initial degrees in Argentina, he has obtained his PhD in 2007 from the Michigan State University in the Laboratory of Cellular Reprogramming. In 2009 he joined the Department of Animal Science of the University of California Davis where he is running his own group and has obtained this year an Associate Professor position.
Pablo presents as a young, energetic and very talented individual. We are convinced that his research will considerably impact the field of large animal transgenesis. His specific niche is that of livestock embryo technologies and stem cells in which he is working by combining studies in a wide range of livestock species – cattle, sheep, horses and pigs. Among his key findings is the derivation and more importantly maintenance of iPS/ES-like cells in livestock species, a domain where the mouse methods are not always applicable. In parallel he is active in producing and characterizing novel gene edited and transgenic livestocks using for instance the CRISPR/Cas9 technology, and has more recently developed new approaches for interspecies blastocyst complementation, combining primate stem cells and livestock host embryos.
Dr. Pablo Ross will attend the next 13th Transgenic Technology (TT2016) meeting in Prague (Czech Republik, 20-23 March 2016) where he will receive the corresponding diploma and will deliver a talk summarizing his scientific achievements and giving us a unique opportunity to hear and learn more about the major recents achievements of the pioneers and current key players in the field.
For the first time the ISTT will be awarding the Young Investigator Award to a scientist belonging to the group of molecular biologists and geneticists working with livestock animals and dealing and investigating with non-rodent species. In fact, they concentrate their work on species which have an obvious and increasing potential impact in our Society, namely species that we eat, that better match our human physiology and can be used as models that can be better utilized for the understanding and treatment of human diseases.
The following articles represent some of his recent findings published in the last years, highlighting his most recent contributions to the field. These publications have had a tremendous impact in the animal transgenesis field.
Schroeder DI, Jayashankar K, Douglas KC, Thirkill TL, York D, Dickinson PJ, Williams LE, Samollow PB, Ross PJ, Bannasch DL, Douglas GC, LaSalle JM. Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas. PLoS Genet. 2015; Aug 4;11(8):e1005442. doi: 10.1371
Wu J, Okamura D, Li M, Suzuki K, Luo K, Ma L, He L, Li Z, Benner C, Tamura I, Krause MN, Nery J, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara G, Guillen P, Campistol J, Rodríguez Esteban C, Ross PJ, Saghatelian A, Ren B, Ecker J, Izpisua Belmonte JC. A spatially defined pluripotent state confers interspecies chimera competency. Nature 2015; 521: 316–321
Ferré LB, Bogliotti Y, Chitwood JL, Fresno C, Ortega HH, Kjelland ME, Ross PJ. Comparison of different fertilisation media for an in vitro maturation/fertilisation/culture system using flow-cytometrically sorted X chromosome-bearing spermatozoa for bovine embryo production. Reprod Fertil Dev. 2015 May 13. doi: 10.1071/RD15019.
Choi YH, Ross P, Velez IC, Macías-García B, Riera FL, Hinrichs K. Cell lineage allocation in equine blastocysts produced in vitro under varying glucose concentrations. Reproduction. 2015;150(1):31-41.
Mohamad-Fauzi N, Ross PJ, Maga EA, Murray JD. Impact of source tissue and ex vivo expansion on the characterization of goat mesenchymal stem cells. J Anim Sci Biotechnol. 2015 Jan 11;6(1):1. doi: 10.1186
Reyes JM, Chitwood JL, and Ross PJ. RNA-seq profiling of bovine oocyte transcript abundance and its modulation by cytoplasmic polyadenylation. Mol Reprod Dev. 2015; 82(2):103-14
Buell M, Chitwood JL, Ross PJ. cAMP modulation during sheep in vitro oocyte maturation delays progression of meiosis without affecting oocyte parthenogenetic developmental competence. Anim Reprod Sci. 2015; 154:16-24.
Bogliotti YS and Ross PJ. Molecular mechanisms of transcriptional and chromatin remodeling around embryonic genome activation. Animal Reproduction. 2015; 12:52-61
Bakhtari A and Ross PJ. DPPA3 prevents cytosine hydroxymethylation of the maternal pronucleus and is required for normal development in bovine embryos. Epigenetics 2014; 9(9):1271-9.
Iqbal K, Chitwood JL, Meyers-Brown GA, Roser JF, Ross PJ. RNA-Seq Transcriptome Profiling of Equine Inner Cell Mass and Trophectoderm. Biol Reprod. 2014; 90(3): 61.
Arias ME, Ross PJ, Felmer R. Culture medium composition affects the gene expression pattern and in vitro developmental potential of bovine somatic cell nuclear transfer (SCNT) embryos. Biol Res. 2013; 46(4):452-62.
Burruel V, Klooster KL, Chitwood J, Ross PJ, Meyers SA. Oxidative Damage to Rhesus Macaque Spermatozoa Results in Mitotic Arrest and Transcript Abundance Changes in Early Embryos. Biol Reprod. 2013; 89(3):72, 1-11.
Chitwood JL, Rincon G, Kaiser G, Medrano JF, Ross PJ. RNA-seq analysis of single bovine blastocysts. BMC Genomics 2013; 14:350
Bogliotti Y and Ross PJ. Mechanisms of histone H3 lysine 27 trimethylation remodeling during early mammalian development. Epigenetics. 2012; 7(9):976-81.
Cannovas S, Cibelli J, Ross PJ. Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development. Proceedings of the National Academy of Sciences of the USA (PNAS) 2012; 109(7):2400-5
Kujjo LL, Ronningen R, Ross P, Pereira RJ, Rodriguez R, Beyhan Z, Goissis MD, Baumann T, Kagawa W, Camsari C, Smith GW, Kurumizaka H, Yokoyama S, Cibelli JB, Perez GI RAD51 Plays a Crucial Role in Halting Cell Death Program Induced by Ionizing Radiation in Bovine Oocytes. Biol Reprod. 2012; 86(3):76.
The 2016 ISTT Young Investigator Committee was formed by Jan Parker-Thornburg (President of ISTT), Dr. Benoît Kanzler (Vice-President of ISTT, Chair), Dr. Paul Sheiffele (iTL CEO) and Dr. Lluis Montoliu (previous ISTT President). Dr. Ross was nominated by ISTT Member Dr. Bruce Whitelaw (The Roslin Institute, University of Edinburgh, Scotland, UK).