Today, the International Society for Transgenic Technologies (ISTT) is six years old. We started to discuss the idea of founding this Society shortly after the 6th Transgenic Technology meeting (TT2005), held in Barcelona in September 2005, and, thereafter, it took us only a couple of months, with the great help of a few highly devoted and generous people, to find out what was required and, eventually, to register the Society in a country, Spain, at the International level. The official registration took place on January 18th, 2006, exactly six years ago. Nowadays, we are running and enjoying a Society with almost 600 members, very actively involved in many meetings, workshops, courses where the common thread is the discussion, training, education on all aspects of the generation and analysis of genetically modified animals, according to our Society aims, and as indicated in our Society bylaws. Let’s celebrate this sixth anniversary. Please join us in raising your glasses in this toast, and say along with us: Happy Birthday ISTT!!!