Patents in ES cell work

mouse ES cells

Recently, at the tg-list, it was discussed the issue of patents that apply in the standard ES cell work. Those patents include the usual positive-negative selection and the use of isogenic DNA. Of course, there are many more with modifications or alternative methodologies but I believe these two methodology are still the basic ones.

According to the United States Patent and Trademark Office, these are the patents alive and active:

Positive-negative selection methods and vectors
Capecchi; Mario R., Thomas; Kirk R.
US Patent: 5,464,764
Issued: November 7, 1995
Filed: February 4, 1993
Assignee: University of Utah Research Foundation (Salt Lake City, UT)

Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
Capecchi; Mario R., Thomas; Kirk R.
US Patent: 5,487,992
Issued: January 30, 1996
Filed: June 28, 1993
Assignee: University of Utah Research Foundation (Salt Lake City, UT)

Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
Capecchi; Mario R., Thomas; Kirk R.
US Patent: 5,627,059
Issued: May 6, 1997
Filed: June 5, 1995
Assignee: University of Utah (Salt Lake City, UT)

Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
Capecchi; Mario R., Thomas; Kirk R.
US Patent: 5,631,153
Issued: May 20, 1997
Filed: June 5, 1995
Assignee: University of Utah (Salt Lake City, UT)

Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
Capecchi; Mario R., Thomas; Kirk R.
US Patent: 6,204,061
Issued: March 20, 2001
Filed: January 9, 1997
Assignee: University of Utah Research Foundation (Salt Lake City, UT)

Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
Capecchi; Mario R., Thomas; Kirk R.
US Patent: 6,204,061
Issued: February 10, 2004
Filed: November 28, 2000
Assignee: University of Utah Research Foundation (Salt Lake City, UT)

Gene targeting in animal cells using isogenic DNA constructs
Berns; Anton, Robanus Maandag; Els, te Riele; Hein
US Patent: 5,789,215
Issued: August 4, 1998
Filed: August 7, 1997
Assignee: GenPharm International (San Jose, CA)

High efficiency gene targeting in mouse embryonic stem cells
Berns; Anton, Robanus Maandag; Els, te Riele; Hein
US Patent: 6,653,113
Issued: November 25, 2003
Filed: February 19, 1999
Assignee: Genpharm International, Inc. (Mountain View, CA)

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