ISTT Prize awarded to Brigid Hogan

Prof. Brigid Hogan (picture from Cell Biology Dep., Duke Univ. Medical Center)

Prof. Brigid Hogan, chair of the department of Cell Biology, at Duke University Medical Center (Durham, NC, USA), will be awarded the sixth ISTT Prize for her “outstanding contributions to the field of transgene technologies” during the next Transgenic Technology meeting (TT2008) that will be held in Toronto (Ontario, Canada) on October 27-29, 2008.

Brigid Hogan has been intimately associated with the Transgenic Technology field since its very beginning. She took part as instructor in the first Molecular Embriology of the Mouse practical courses organised in 1983 and 1984, held at Cold Spring Harbor Laboratory, shortly after the first publications about the generation of transgenic mice. These pioneer courses eventually resulted in the well-known “Mouse manual” (Manipulating the mouse embryo: a laboratory manual, Cold Spring Harbor Laboratory Press), first published in 1986 (edited by Brigid Hogan, Frank Constantini and Elizabeth Lacey) and revised in 1994, in its second edition (edited by Brigid Hogan, Rosa Beddington, Frank Constantini and Elizabeth Lacey) before the current (2003) third edition was available (edited by Andras Nagy, Marina Gertsenstein, Kristina Vintersten and Richard Behringer). Generations of scientists and technicians have learnt how to generate transgenic mice and all associated technologies through this book, the most influential and a reference in the field.

In addition to her instrumental contributions to the field of transgenic technologies Brigid Hogan is a most prestigious scientist and a world recognised expert in developmental biology and stem cell research. Research in her laboratory currently is focused “on the basic mechanisms underlying organogenesis and tissue repair, and how these two processes involve stem cells“. In particular, she studies “the development, maintenance, and repair of the foregut and lung, using the mouse as a model genetic organism“. A list of her publications from 1998 to 2006 is available here, whereas her most recent publications in 2007 and 2008 are listed below.

Corriere MA, Rogers CM, Eliason JL, Faulk J, Kume T, Hogan BL, Guzman RJ. Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation.
J Surg Res. 2008 Mar;145(1):142-9.

Hogan B. A shared vision.
Dev Cell. 2007 Dec;13(6):769-71.

Lu Y, Thomson JM, Wong HY, Hammond SM, Hogan BL. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells.
Dev Biol. 2007 Oct 15;310(2):442-53.

Rossant J, Hogan B. Retrospective. Anne McLaren (1927-2007).
Science. 2007 Aug 3;317(5838):609.

Kizhatil K, Davis JQ, Davis L, Hoffman J, Hogan BL, Bennett V. Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos.
J Biol Chem. 2007 Sep 7;282(36):26552-61.

Sharova LV, Sharov AA, Piao Y, Shaik N, Sullivan T, Stewart CL, Hogan BL, Ko MS. Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains.
Dev Biol. 2007 Jul 15;307(2):446-59.

Que J, Okubo T, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.
Development. 2007 Jul;134(13):2521-31.

Cox B, Kislinger T, Wigle DA, Kannan A, Brown K, Okubo T, Hogan B, Jurisica I, Frey B, Rossant J, Emili A. Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes.
Mol Syst Biol. 2007;3:109.

Rawlins EL, Ostrowski LE, Randell SH, Hogan BL. Lung development and repair: contribution of the ciliated lineage.
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):410-7.

Along with a Diploma for the ISTT Prize Brigid Hoganwill be awarded honorary ISTT Membership and a silver-made sculpture representing a mouse blastocyst created by the Hungarian artist Bela Roznay. Brigid Hogan will also deliver a lecture at the TT2008 Meeting in Toronto entitled: “Transgenic mouse models of lung development and disease“.

ISTT Prize

Previous scientists awarded with the ISTT Prize: Charles Babinet (at TT2007, Brisbane, Australia), Andras Nagy (at TT2005, Barcelona, Spain), Qi Zhou (at TT2004, Uppsala, Sweden), Kenneth McCreath (at TT2002, Munich, Germany) and Teruhiko Wakayama (at TT2001, Stockholm, Sweden).

The ISTT Prize is generously sponsored by genOway.

The KOMP Repository: Mouse KO project

KOMP

KOMP stands for Knock-Out Mouse Project, and it is a public academic trans-initiative, funded by NIH, that aims “to generate a comprehensive and public resource comprised of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome“.

Together and in coordination with the Canadian NorCOMM and European EUCOMM initiatives, the KOMP repository, acting as a coordination center, allows to search for genes that have been inactivated, those that are being knocked-out and those that have not yet been addressed. The researcher can submit an expression of interest describing why a given gene should be knocked-out if the gene of interest is not yet included in the priority list.

The KOMP Repository hosts the vectors, ES cells, mice, embryos, and sperm generated by the NIH KOMP Mutagenesis Project. It is highly advisable these days to search for the status of KO of a given gene before starting a new KO mouse project in the laboratory (i.e. by searching through the catalog provided at the KOMP WEB page, or searching through the several gene-trap initiatives). It could be that the gene is actually already being knocked out by one of these initiatives.

The First Brazilian Symposium on Transgenic Technology (1st BSTT): a most successful event

Prof. Oliver Smithies and Prof. Joao Bosco Pesquero

The first Brazilian Symposium on Transgenic Technology (1st BSTT) was held in Sao Paulo on March 10-12, 2008. More than 300 participants attended this most successful and interesting event, organized by Prof. Dr. Joao Bosco Pesquero, Dra. Heloisa Allegro Baptista and their colleagues from the Universidade Federale de Sao Paulo (UNIFESP). This symposium was supported and co-sponsored by the International Society for Transgenic Technologies.

This meeting included the remarkable participation of Prof. Dr. Oliver Smithies, 2007 Nobel Prize in Physiology or Medicine for “for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells“, along with several international experts within the field of animal transgenesis, who shared their results with their Brazilian colleagues, resulting in a comprehensive scientific program that covered the majority of aspects in animal transgenesis.

This symposium represents a milestone, an important step towards the dissemination and use of methods for the generation and analyses of all types of genetically modified animals in Brazil, to be applied in Biology, Medicine, Animal Health and Biotechnology.